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> Kojic Acid |
A fungal metabolic product, kojic acid inhibits the catecholase
activity of tyrosinase, which is the rate-limiting, essential
enzyme in the biosynthesis of the skin pigment melanin. Kojic
acid also is consumed widely in the Japanese diet with the belief
that it is of benefit to health. Indeed, it has been shown to
significantly enhance neutrophil phagocytosis and lymphocyte
proliferation stimulated by phytohemagglutinin. Melanocytes
treated with kojic acid become nondendritic with a decreased
melanin content. Additionally, it scavenges reactive oxygen
species that are excessively released from cells or generated
in tissue or blood.
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